Protein Details: Potassium channel subfamily K member 9

Protein ID

ICDB_Pro_1485

Protein Name

Potassium channel subfamily K member 9

Gene Name

Kcnk9; Task3

Organism

Rattus norvegicus (Rat)

Length

396 amino acids

AlphaFoldDB

AF-Q9ES08-F1-model_v4.pdb

Function

pH-dependent; voltage-insensitive; background potassium channel protein.

Sequence

MKRQNVRTLSLIACTFTYLLVGAAVFDALESDHEMREEEKLKAEEVRLRGKYNISSDDYQQLELVILQSEPHRAGVQWKFAGSFYFAITVITTIGYGHAAPGTDAGKAFCMFYAVLGIPLTLVMFQSLGERMNTFVRYLLKRIKKCCGMRNTEVSMENMVTVGFFSCMGTLCLGAAAFSQCEDWSFFHAYYYCFITLTTIGFGDFVALQSKGALQRKPFYVAFSFMYILVGLTVIGAFLNLVVLRFLTMNTDEDLLEGEVAQILAGNPRRVVVRVPQSRKRHHPMYFLRKYGRTLCYLCFPGANWGDDDDDDDDAVENVVVTTPVPPAVAAAAAAATPGPSTRNVRATVHSVSCRVEEIPPDVLRNTYFRSPFGAIPPGMHTCGENHRLHIRRKSI

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Highly expressed in the CNS and at lower levels in the colon; kidney; liver; lung; spleen; stomach and skeletal muscle. The highest expression was found in the olfactory nuclei; piriform cortex; cerebellum; antedorsal thalmic nucleus; pontine nucleus; dorsal raphe and several nuclei in the medulla. Shows a non-homogeneous distribution in the hippocampus. Shows a non-homogeneous distribution in the hippocampus. Shows a non-homogeneous distribution in the hippocampus. Expressed at highest levels in the lateral posterior and inferior portions and at medium levels in neocortex

DOI ID

10.1074/jbc.275.13.9340; 10.1210/mend.16.3.0788; 10.1152/jn.2001.86.1.130; 10.1006/mcne.2001.1045

RefSeq

NP_445857.2; XP_017450625.1